OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Ryan Kelly, Danny Pinter OR Tanor Bortolini
- RG: Will Fries, Dalton Tucker
- RT: Braden Smith, Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- Jonathan Taylor had 12 carries for 103 yards against the Green Bay Packers in the Colts' Week 2 loss. He also had receptions of 14 and 18 yards.
- Alec Pierce scored his second touchdown of the 2024 season, and the only one in the Colts' loss to the Packers, on Sunday. Pierce led the team with five receptions for 56 yards.
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Adetomiwa Adebawore
- NT: Grover Stewart, Taven Bryan, Raekwon Davis
- DE: Tyquan Lewis, Dayo Odeyingbo, Isaiah Land
- WLB: E.J. Speed
- MLB: Zaire Franklin, Segun Olubi
- SAM: Jaylon Carlies, Grant Stuard
- CB: Dallis Flowers, Chris Lammons
- FS: Nick Cross, Rodney Thomas II, Trevor Denbow
- SS: Julian Blackmon
- N: Kenny Moore II
- CB: Jaylon Jones, Samuel Womack III
- Nick Cross led the Colts with 15 tackles (10 solo) against the Packers, and leads the team with 29 tackles (18 solo) across the first two games of the season.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Anthony Gould OR Dallis Flowers, Josh Downs
- PR: Anthony Gould, Josh Downs, Dallis Flowers
