OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Tanor Bortolini, Danny Pinter
- RG: Dalton Tucker
- RT: Braden Smith, Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Joe Flacco, Anthony Richardson, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- Adonai Mitchell had a career-high 71 yards on six receptions in the Colts' Week 10 game against the Buffalo Bills.
- Alec Pierce led the Colts with four receptions for 81 yards and a touchdown -- his fourth of the season for a new career-high -- against the Bills.
- Jonathan Taylor had 21 carries for 114 yards against the Bills in his 20th career 100-yard game.
DEFENSE
- DE: Kwity Paye, Laiatu Latu, Genard Avery
- DT: DeForest Buckner, Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Isaiah Land, Adam Gotsis
- WLB: E.J. Speed
- MLB: Zaire Franklin, Segun Olubi
- SAM: Grant Stuard, Cameron McGrone
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II, Darren Hall
- SS: Nick Cross, Ronnie Harrison Jr.
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Kenny Moore II and E.J. Speed each had one interception against the Bills. Speed's interception was the first of his career.
- Zaire Franklin totaled nine tackles (five solo) against the Bills, bringing him to 105 total tackles on the season. Franklin is the first player to reach 100 tackles this season.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
