OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Tanor Bortolini, Danny Pinter
- RG: Dalton Tucker, Atonio Mafi
- RT: Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- In the Colts' Week 15 loss to the Denver Broncos, Anthony Richardson completed 17 of 38 passes for 172 yards and had seven carries for 46 yards and a touchdown.
- Kylen Granson recorded single-game season highs in receptions (three) and receiving yards (47) against the Broncos.
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Tyquan Lewis, Isaiah Land
- WLB: E.J. Speed
- MLB: Zaire Franklin, Segun Olubi
- SAM: Grant Stuard, Cameron McGrone
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II, Darren Hall
- SS: Nick Cross, Ronnie Harrison Jr.
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Zaire Franklin recorded nine tackles (six solo), two tackles for loss and his second interception of the season (third of his career).
- Nick Cross and Samuel Womack III joined Franklin as the two other Colts players to record interceptions against the Broncos. Cross also tallied four tackles (two solo) and Womack had two solo tackles in the loss.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
