OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Ryan Kelly, Danny Pinter OR Tanor Bortolini
- RG: Mark Glowinski, Tanor Bortolini OR Dalton Tucker
- RT: Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- In the Colts' Week 17 loss to the New York Giants, Alec Pierce had six receptions for 122 yards and a touchdown for his fourth 100-yard receiving game of his career. Pierce now leads the Colts with 767 receiving yards and six receiving touchdowns, and is averaging 21.9 yards per reception.
- Michael Pittman Jr. tallied a season-high nine receptions for 109 yards and a touchdown against the Giants, for his 10th 100-yard receiving game of his career.
- Jonathan Taylor had 32 carries for 125 yards and two touchdowns against the Giants.
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Tyquan Lewis, Isaiah Land
- WLB: E.J. Speed, Grant Stuard
- MLB: Zaire Franklin, Segun Olubi
- SAM: Jaylon Carlies, Cameron McGrone
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II
- SS: Nick Cross, Ronnie Harrison Jr.
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Zaire Franklin led the Colts with 14 tackles (7 solo) in the team's loss to the Giants and set a new single-game career-high in tackles for loss with four.
- Nick Cross recorded seven tackles (two solo) against the Giants.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
