OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Ryan Kelly, Danny Pinter OR Tanor Bortolini
- RG: Mark Glowinski, Tanor Bortolini OR Dalton Tucker
- RT: Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- In the Colts' Week 16 win over the Tennessee Titans, Jonathan Taylor tallied 29 carries for 218 yards and three rushing touchdowns. In doing so, Taylor joined Edgerrin James as the only two players in franchise history to pass 200 rushing yards in a single game. He is also one of three players (James, Marshall Faulk) in team history to have multiple games with at least three rushing touchdowns. On Tuesday, Taylor earned AFC Offensive Player of the Week for his efforts.
- In Sunday's win over the Titans, Jonathan Taylor and Anthony Richardson made history as the first running back/quarterback duo in the NFL to rushing for at least 70 yards (Richardson rushed for a single-game career-high 70 yards in the contest) and at least 200 yards (Taylor totaled 218).
- The Colts' offense set a franchise record on Sunday with 335 total rushing yards.
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Tyquan Lewis, Isaiah Land
- WLB: E.J. Speed, Grant Stuard
- MLB: Zaire Franklin, Segun Olubi
- SAM: Jaylon Carlies, Cameron McGrone
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II
- SS: Nick Cross, Ronnie Harrison Jr.
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Jaylon Carlies, playing in his first game since Week 7, recorded a team-high and single-game career high 10 tackles (6 solo) against the Titans.
- Kenny Moore II snagged two interceptions against the Titans; he has three this season and 20 in his NFL career.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
