OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Ryan Kelly, Danny Pinter OR Tanor Bortolini
- RG: Dalton Tucker
- RT: Braden Smith, Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- Alec Pierce had three receptions for 134 yards and a touchdown in the Colts' loss to the Jacksonville Jaguars, marking the wide receiver's third career game with over 100 receiving yards. Pierce also leads the NFL with an average of 28.3 yards per catch.
- Joe Flacco was completed 33 passes for 359 yards and three touchdowns against the Jaguars; Anthony Richardson (oblique) did not play.
- Trey Sermon and Tyler Goodson split running back duties on Sunday with Jonathan Taylor (ankle) sidelined. Sermon had 10 carries for 38 yards and a touchdown, and Goodson had five carries for 26 yards.
DEFENSE
- DE: Kwity Paye, Laiatu Latu, Genard Avery
- DT: Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Isaiah Land, Adam Gotsis
- WLB: E.J. Speed
- MLB: Zaire Franklin, Segun Olubi
- SAM: Jaylon Carlies, Grant Stuard
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II
- SS: Nick Cross, Trevor Denbow
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Zaire Franklin was the only Colts player to record double-digit tackles against the Jaguars with 10 (. Franklin is third on the team with 23 total tackles, behind E.J. Speed (40) and Nick Cross (33).
- Jaylon Jones tallied six tackles (five solo) and two passes defensed against the Jaguars. He also recorded his first career forced fumble.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
