OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Tanor Bortolini, Danny Pinter
- RG: Dalton Tucker
- RT: Braden Smith, Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- Anthony Richardson completed 11-of-28 passes for 172 yards against the Detroit Lions on Sunday. He also had 10 carries for 61 yards.
- Michael Pittman Jr. led the Colts in receptions (six) and receiving yards (96) on Sunday. He passed T.Y. Hilton (374) for the second-most receptions by a Colts player in their first five seasons, and he passed Reggie Wayne (4,164) for the fourth-most receiving yards by a Colts player in their first five seasons.
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Taven Bryan, Adetomiwa Adebawore
- NT: Grover Stewart, Raekwon Davis
- DE: Dayo Odeyingbo, Tyquan Lewis, Isaiah Land
- WLB: E.J. Speed, Liam Anderson
- MLB: Zaire Franklin, Segun Olubi
- SAM: Grant Stuard, Cameron McGrone
- CB: Samuel Womack III, David Long Jr.
- FS: Julian Blackmon, Rodney Thomas II, Darren Hall
- SS: Nick Cross, Ronnie Harrison Jr.
- N: Kenny Moore II, Chris Lammons
- CB: Jaylon Jones
- Laiatu Latu tallied four tackles (two solo), one tackle for loss, one sack and one forced fumble against the Lions.
- Nick Cross led the team in tackles with 14 on Sunday. Zaire Franklin and E.J. Speed also tallied double-digit tackles with 13 and 11, respectively.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Tyler Goodson, Anthony Gould, Ashton Dulin
- PR: Josh Downs, Anthony Gould
