OFFENSE
- WR: Michael Pittman Jr., Ashton Dulin
- LT: Bernhard Raimann, Blake Freeland
- LG: Quenton Nelson, Danny Pinter OR Tanor Bortolini
- C: Ryan Kelly, Danny Pinter OR Tanor Bortolini
- RG: Will Fries, Dalton Tucker
- RT: Braden Smith, Matt Goncalves
- TE: Mo Alie-Cox, Drew Ogletree
- TE: Kylen Granson, Will Mallory
- WR: Josh Downs, Anthony Gould
- WR: Alec Pierce OR Adonai Mitchell
- QB: Anthony Richardson, Joe Flacco, Sam Ehlinger
- RB: Jonathan Taylor, Trey Sermon, Tyler Goodson
- Alec Pierce had a career game in Week 1 against the Houston Texans, with three receptions on three targets for 125 yards, setting career-highs in receiving yards and longest reception (60 yards). He scored the Colts' first touchdown of 2024 on a 60-yard pass from Anthony Richardson.
- Richardson finished Sunday's game with nine completions on 19 attempts for 212 yards, and became one of just six quarterbacks in the last 10 seasons to complete multiple passes that traveled at least 55 yards past the line of scrimmage (the 60-yard touchdown pass to Pierce and 57-yard heave to Pierce in the third quarter).
DEFENSE
- DE: Kwity Paye, Laiatu Latu
- DT: DeForest Buckner, Adetomiwa Adebawore
- NT: Grover Stewart, Taven Bryan, Raekwon Davis
- DE: Tyquan Lewis, Dayo Odeyingbo, Isaiah Land
- WLB: E.J. Speed
- MLB: Zaire Franklin, Segun Olubi
- SAM: Jaylon Carlies, Grant Stuard
- CB: JuJu Brents, Dallis Flowers
- FS: Nick Cross, Rodney Thomas II, Trevor Denbow
- SS: Julian Blackmon
- N: Kenny Moore II
- CB: Jaylon Jones, Samuel Womack III
- Segun Olubi made an impact on special teams in the Colts' loss to the Texans, blocking a punt which the Colts then turned into a Jonathan Taylor touchdown on the next play. In doing so, Olubi became one of four Colts linebackers to have a blocked punt in his career.
- The Colts recorded four sacks against the Texans, thanks to DeForest Bucker, Kwity Paye, Tyquan Lewis and Dayo Odeyingbo.
SPECIALISTS
- P: Rigoberto Sanchez
- PK: Matt Gay
- H: Rigoberto Sanchez
- LS: Luke Rhodes
- KR: Anthony Gould OR Dallis Flowers, Josh Downs
- PR: Anthony Gould, Josh Downs, Dallis Flowers
