The Colts announced six inactive players for Week 15's game against the New England Patriots:
- C Ryan Kelly (knee/illness/not-injury related – personal matter)
- WR Mike Strachan
- RB Marlon Mack
- LB Malik Jefferson
- DE Ben Banogu
- T Julién Davenport
Prior to kickoff, the Colts activated LB Zaire Franklin from the Reserve/COVID-19 list, elevated DT Chris Williams to the active roster from the practice squad and placed DT Antwaun Woods on injured reserve.