The Colts on Friday ruled out cornerback Kenny Moore II (hip), defensive end Kwity Paye (quad) and running back Jonathan Taylor for their Week 5 game against the Jacksonville Jaguars at EverBank Stadium.
Quarterback Anthony Richardson (oblique) was listed as questionable on Friday. He was limited during practices this week.
"We'll see," head coach Shane Steichen said on Richardson.
Taylor did not participate in practice Wednesday, Thursday and Friday.
"It'll be running back by committee this week," Steichen said, noting the team has confidence in backups Trey Sermon and Tyler Goodson.
Paye and Moore sustained their injuries in the Colts' Week 3 win over the Chicago Bears and did not practice this week.
Center Ryan Kelly (center) and right tackle Braden Smith (knee) are both listed as questionable as well.
The Colts' final practice report of Week 5:
